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Optimal Antimicrobial Action at 400-420nm

Third-party, peer-reviewed studies confirm that ActiveCLEAN’s^™ 405-nanometer, non-UV lighting was 98+% effective¹ against SARS-CoV-2, the virus that causes COVID-19, in just four hours.

Kill 98+% of COVID-19
With Non-UV 
ActiveCLEAN^™

Effective against bacteria, fungi, yeasts and mold in laboratory and controlled-room experiments.

90^+%

ActiveCLEAN^TM LED Technology and Viruses 

FAQ

ActiveCLEAN^TM recently announced the efficacy of its antimicrobial light technology for the inactivation of viruses.

The antimicrobial effects of visible light (405 nanometers) on bacteria, mold, fungi and yeast have previously been well-studied and documented for many years.

Only recently have active investigations been conducted on the effects of these antimicrobial lights on non-enveloped viruses and enveloped viruses. The results of these tests have verified the antimicrobial impact on multiple classes of viruses.

Below are frequently asked questions about ActiveCLEAN’s impact on viruses—and their answers:

1. Do you kill variants of SARS-CoV-2? 

Yes, the genetic variants should not affect structural aspects that are impacted by ActiveCLEAN^TM lighting. 

2. Does ActiveCLEAN™ kill the common cold? 

ActiveCLEAN’s™ illumination has proven efficacious with nonenveloped and enveloped viruses. The rhinovirus is nonenveloped.

3. How long does it take to kill viruses? 

ActiveCLEAN’s™ illumination has proven efficacious with nonenveloped and enveloped viruses. The rhinovirus is nonenveloped.

 
4 What is the difference between a non-enveloped virus and an enveloped virus? 

Viruses can infect human, animal plant or bacterial cells, and they can be classified based on two criteria:

•    Their type of genetic material (DNA or RNA)
•    Their structure, like being enveloped or non-enveloped.

The structure of all viruses includes a protein shell called a “capsid.”

Enveloped Viruses

Enveloped viruses have an additional layer that covers the capsid. This membrane is composed of lipids and proteins it “stole” from the host cells and viral glycoproteins (sugars combined with proteins). The bumps, knobs and spikes that artists use in images of enveloped viruses like SARS-CoV-2 depict structures on the viral envelope.

These types of viruses need both an intact capsid and the envelope to infect cells. The envelope also helps avoid detection by the host immune system because it makes the virus look like just another host cell.

But the envelope also provides a soft target for destroying the virus when it is outside the host. Common disinfectants—and even alcohol, detergents or soap—can disrupt the oily envelope and its components, destroying the ability of the virus to infect host cells.
Enveloped viruses can cause persistent infections and must be transferred from host to host. Examples of enveloped viruses include ones that cause diseases in humans, such as COVID-19, Influenza, Hepatitis B and C and Hemorrhagic Fever (Ebola Virus Disease). 

Non-enveloped Viruses 

Non-enveloped viruses do not have a lipid covering, but their effects on humans can be just as devastating. These “naked” viruses only need their protein-based capsid and host detector proteins to infect host cells. However, because they lack a lipid envelope, they are more resistant to many disinfectants and other stresses like drying out or heat exposure.

Examples of non-enveloped viruses include types that can cause dysentery (Norovirus), common colds (Rhinovirus) and Polio (Poliovirus).

5. How does ActiveCLEAN™ kill viruses? 

The mechanism of action is unknown, but based on a comparison of different datasets, the likely target is externally facing proteins (like the COVID spike protein) that enable viruses to bind to their host cells. Changing these proteins renders them unable to breach and infect cells.

 
6. What tests were performed that indicate 405nm visible light can inactivate viruses? 

Performed through a certified third-party testing lab, ActiveCLEAN’s first studies were done using non-enveloped viruses.

Non-enveloped viruses were chosen for the first studies primarily because these viruses are harder to destroy or inactivate than enveloped viruses. Enveloped viruses have a membrane in addition to the protein coat. This membrane is relatively fragile and can more easily be disrupted to inactivate this class of virus.

Recent studies performed by several independent labs and institutions have shown that light in the 405-nanometer region was able to inactivate enveloped viruses in simple salt solutions with no additives. These results converge to demonstrate efficacy, in various testing conditions, on both enveloped and non-enveloped viruses. This will also encourage more research to enhance the understanding of the effects of 405-nanometer light on viral components.

7. What were the results of ActiveCLEAN’s third-party tests? 

ActiveCLEAN’s testing, performed by a third-party independent testing laboratory (Microchem, Texas), was conducted using MS2, which is a non-enveloped virus.

After six hours dried from a standard saline solution, over a 3.82 log reduction (99.985%) was achieved. After six hours dried from artificial saliva, a 2.23 log reduction (99.41%) was achieved. This testing was conducted at 2 mW/cm2, as a starting point. This would represent a generally higher light level than what would be expected in an overhead room application.

However, the benchtop test unit used was designed to adjust luminosity to replicate various room lighting conditions, as testing protocols expand to continue to test various conditions and intensities. Additionally, external third-party research labs have pre-published viral efficacy data on 405-nanometer wavelengths at lower intensities, similar to an expected overhead room environment.

8. How does 405nm light kill/inactivate viruses? 

Based on currently available research literature, it is suggested that 405-nanometer light can destabilize the membrane of enveloped viruses and to a lesser extent the protein coat of non-enveloped viruses (though the potency of the effect may increase in biological fluids).

A definitive answer to the mode of action of 405-nanometer light during the demonstrated inactivation of viruses is still on the horizon.

9. Does ActiveCLEAN^TM kill viruses on surfaces and in the air? 

Based on the results of ActiveCLEAN’s testing, it is confirmed that ActiveCLEAN^TM antimicrobial lights directly impact viruses on surfaces.

As the exciting data are rapidly accumulating on the effectiveness of 405-nanometer light on both non-enveloped and enveloped viruses, ActiveCLEAN^TM anticipates expanded research with its proprietary antimicrobial light technology and inactivation of viruses in a growing set of environmental conditions, including air.

Important data on the effectiveness of viral destruction in aerosol form are needed to understand how overhead light levels impact enveloped viruses like SARS-CoV-2 in the air. Non-enveloped viruses like those that cause the common cold are often transferred by surface contact. Research will continue in this area to accumulate a greater understanding of various test environments as well as various room light intensities.

10. How long can viruses live on surfaces? 

Virus-laden droplets may remain infectious for several hours, depending on where they fall.

Viruses generally remain active longer on stainless steel, plastic and similar hard surfaces than on fabric and other soft surfaces. Other factors, such as the amount of virus deposited on a surface and the temperature and humidity of the environment, also determine how long viruses stay active outside the body.

It is possible to catch a virus, like the flu or a cold, after handling an object an infected person sneezed or coughed on a few moments ago. While each specific virus is different and unique, personal contact with an infected person—such as a handshake or breathing in droplets from a cough or sneeze—can be the most common way these viruses spread.

11. How long does it take for ActiveCLEAN^TM antimicrobial LED lights to inactivate and kill viruses on surfaces? 

After six hours dried from a saline solution, over a 3.82 log reduction (99.985%) was achieved on a non-enveloped virus (MS2). After 6 hours dried from artificial saliva, a 2.23 log reduction (99.41%) was achieved with this same virus. Results may vary depending on the amount of light that is reaching the surfaces in the space where ActiveClean’s technology is installed and the length of time of exposure.

12. Can people be exposed to ActiveCLEAN^TM antimicrobial light that impacts viruses? 

Yes. ActiveCLEAN^TM antimicrobial lights fall within the visible light spectrum (between 400 and 420 nanometers), outside the spectrum of potentially damaging UV (ultraviolet) light.

ActiveCLEAN^TM LED technology meets international standards (IEC62471) for continuous and unrestricted use around people, animals and plants. These same lights are used when addressing viruses, bacteria, fungi yeast or mold.

13. Are people safe from viruses when they are under these lights? Do we still need to social distance and wear masks while under these lights?

Many viruses are spread from host-to-host. Although viruses can be picked up from touching surfaces where the virus has been deposited, viruses like SARS-CoV-2 are mostly spread through airborne transmission. While under ActiveClean’s lights it remains important to follow CDC guidelines of mask wearing, social distancing and washing hands.

14. What is the difference between a virus and a bacterium? 

Bacteria and viruses are both small, but bacteria are very complex organisms that can and do adapt constantly to their environment, the available nutrients and even the size of the bacterial crowd they inhabit.

Viruses are extremely simple, lacking any means of energy production, environmental sensing or response. They cannot reproduce without the taking over the machinery of a larger, complex living cell (“a host”).

15. What is a host? 

A host is the living cell of an animal, plant or bacterium that a virus uses as a factory to reproduce and spread itself. Viruses on their own are inert—but once inside a host cell they commandeer, the cell’s complex biological systems to make numerous copies of themselves and release them into the environment to continue their existence.

16. Are viruses living microbes? 

Most scientists would say no because viruses cannot reproduce (replicate) without a host or remain viable in the environment outside of a host. Being able to replicate oneself is generally accepted as a central tenet of the definition of life.

17. Do I say prevent? Inactivate? Kill? 

Strictly speaking if viruses are not alive, they cannot be killed. However, in common parlance killing viruses carries the same meaning as the more scientifically correct term "inactivate.”

You cannot prevent a virus any more than you can prevent a rock, but you can prevent viral infections and viral spread. ActiveCLEAN^TM does not, however, make any claims specific to viral infections and viral spread. The simple answer is stick with inactivate and kill when discussing the technology’s impact on viruses.

18. Is there viral kill in the air? 

ActiveCLEAN^TM lighting affects organisms in the air, based on a published paper and field observations, but there are no standards or measurements tools established yet by the EPA. 

Trusted

Unlike UV light, ActiveCLEAN^TM meets the international standard for unlimited use around people, pets and plants.

Proven

Kills 90% or more of common germs, including 98% of SARS-CoV-2, the virus that causes COVID-19.¹

Fast

Continuously creates inhospitable environments for viruses, bacteria, fungi, yeasts and mold.²

Easy

Simple to install and use, with two automated deep-cleaning modes.

Versatile

Seamlessly fits into businesses of all shapes and sizes including offices, schools, hotels and stores.

ROI

Decreases employee sick days, routine disinfection expenses and business disruptions between workflows.